Molecular pathogenesis of sporadic colorectal cancers
نویسندگان
چکیده
منابع مشابه
Molecular pathogenesis of sporadic colorectal cancers
Colorectal cancer (CRC) results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to adenocarcinoma. Approximately 75% of CRCs are sporadic and occur in people without genetic predisposition or family history of CRC. During the past two decades, sporadic CRCs were classified into three major groups according to frequ...
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Epigenetics are thought to play a major role in the carcinogenesis of multiple sporadic colorectal cancers (CRC). Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers have been analyzed. This study was aimed at describing the epigenetic signature of multiple CRC using a genome-scale DNA methylation profiling. We analyzed 12...
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ژورنال
عنوان ژورنال: Chinese Journal of Cancer
سال: 2016
ISSN: 1944-446X
DOI: 10.1186/s40880-015-0066-y